Translation of insane in Spanish

I am trying to learn Spanish because Spanish is becoming more and more important in the USA because of immigrants. Especially here in Texas. I used to live in Nevada for many years. Boring place, gotta tell ya.
They were floating in self made tubs and rowed with sticks. When they reached our boat they tried to sell us beverage. We vigorously denied them access to our boat. It just did not help.
We walked almost every alley in Cusco, stunned by its beauty and ignoring the developing altitude thickness, which resulted in the most horrible night of our lives.